MuSK-MG: AChE-Hemmer niedrig dosiert + 3,4-DAP möglicherweise effektiv

 

 

 

19. Juli 2014

 

"In MuSK-MG, we suggest that only low-dose acetylcholinesterase (AChE) inhibitors be used to avoid side effects, and we propose that 3,4-DAP may be effective as a symptomatic therapy."


Quelle:
J Neuroimmunol. 2012 Apr;245(1-2):75-8. doi: 10.1016/j.jneuroim.2012.02.010. Epub 2012 Mar 11.
Mori S, Kishi M, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Konishi T, Maruyama N, Shigemoto K:
3,4-Diaminopyridine improves neuromuscular transmission in a MuSK antibody-induced mouse model of myasthenia gravis.